Publications
2023
Xuying Zhang, Guanxi Xiao, Caroline Johnson, Yuheng Cai, Zachary K. Horowitz, Christine Mennicke, Robert Coffey, Mansoor Haider, David Threadgill, Rebecca Eliscu, Michael C. Oldham, Alon Greenbaum, H. Troy Ghashghaei, Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain, iScience, Volume 26, Issue 3, 2023, 106242, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2023.106242. https://www.sciencedirect.com/science/article/pii/S258900422300319X
2022
Muthusamy N., Williams T.I., O’Toole R., Brudvig J.J., Adler K.B., Weimer J.M., Muddiman D.C., Ghashghaei H.T.* (2022) Phosphorylation dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain. Geroscience, doi: 10.1007/s11357-022-00517-3.
Li C., Rai M.R., Ghashghaei H.T., Greenbaum A. (2022) Illumination angle correction during image acquisition in light-sheet microscopy using deep learning. Biomed Opt Express. 13(2):888-901.
C. Li, M. Rai, H. Ghashghaei, and A. Greenbaum. (2022) “Illumination angle correction during image acquisition in light-sheet fluorescence microscopy using deep learning,” Biomed. Opt. Express 13, 888-901. https://doi.org/10.1364/BOE.447392
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Chen Li, Adele Moatti, Xuying Zhang, H Troy Ghashghaei, Alon Greenbaum (2022) Deep learning-based autofocus method
enhances image quality in light-sheet fluorescence microscopy: publisher’s note. https://doi.org/10.1364/BOE.450829
2021
Cai Y, Zhang X, Kovalsky SZ, Ghashghaei HT, Greenbaum A. (2021) Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet. PLoS One. 16(9):e0257426.
Li C, Moatti A, Zhang X, Ghashghaei HT, Greenabum A. (2021) Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy. Biomed Opt Express. 12(8):5214-5226.
2020
Zhang X., Mennicke C.V., Xiao G., Beattie R., Haider M., Hippenmeyer S., Ghashghaei H.T.* (2020) Clonal analysis of gliogenesis in the cerebral cortex reveals stochastic expansion of glia and cell autonomous responses to Egfr dosage. 9(12):2662.
Johnson C.A. and Ghashghaei H.T.* (2020) Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex. Development. 147(4):dev186056.
Wu J., Tian W.J., Liu Y., Wang H.J., Zheng J., Wang X., Pan H., Li J., Luo J., Yang X., Lau L.F, Ghashghaei H.T., Shen Q. (2020) Ependyma restrict the size of neural stem cell pool through CCN1 expression in the adult V-SVZ. EMBO J. 39(5):e101679.
2018
Ehling S., Butler A., Thi S., Ghashghaei H.T., Bäumer W. (2018) To scratch an itch: Establishing a mouse model to determine active brain areas involved in acute histaminergic itch. IBRO Rep. 5:67-73.
Brudvig J., Cain J., Sears R., Schmidt-Grimminger G., Wittchen E., Adler K., Ghashghaei H.T., Weimer J. (2018) MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network. Rep. 8(1):13278
Muthusamy N., Brumm A., Zhang X., Carmichael S.T., Ghashghaei H.T.* (2018) Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain. Rep. 8(1):1766.
2017
Johnson CA, Wright CE, Ghashghaei T.* (2017) Regulation of Cytokinesis during Corticogenesis: Focus on the Midbody. FEBS Lett. [Epub ahead of print] Review
Beattie R, Postiglione MP, Burnett LE, Laukoter S, Streicher C, Pauler FM, Xiao G, Klezovitch O, Vasioukhin V, Ghashghaei T., Hippenmeyer S. (2017) Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells. Neuron. 94(3):517-533.
Davis A., Amin N., Johnson C., Bagley K., Ghashghaei H.T., Nascone-Yoder N. (2017) Stomach Curvature is Generated by Left-right Asymmetric Gut Morphogenesis. Development. 144(8):1477-1483.
Ren Y.^, Ao Y.^, O’Shea T.M., Burda J.E., Bernstein A.M., Brumm A.J., Muthusamy N., Ghashghaei H.T., Carmichael S.T., Cheng L., Sofroniew M.V. (2017) Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury. Sci. Rep.7:41122.
Muthusamy N.^, Zheng X.^, Johnson^, Yadav P.N., Ghashghaei H.T.* (2017) Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning. Nat. Neurosci. 20(1):20-23.
2016
Dwyer N.D.*, Chen B., Chou S.J., Hippenmeyer S., Nguyen L., Ghashghaei H.T.* (2016) Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms Regulating Progenitor Behavior and Productivity. J. Neurosci. 36(45):11394-11401.
Loziuk P., Meier F., JohnsonC., Ghashghaei H.T.*, Muddiman DD*. (2016) TransOmic Analysis in Forebrain Sections of Sp2 Conditional Knockout Embryonic Mice Using IR-MALDESI Imaging and LC-MS-based Proteomics. Anal Bioanal Chem. 408(13):3453-74.
Sai K., Morioka S., Takaesu G., Muthusamy N., Ghashghaei H.T., Hanafusa H., Matsumoto K., Ninomiya-Tsuji J. (2016) TAK1 determines susceptibility to endoplasmic reticulum stress and hypothalamic leptin resistance. J Cell Sci. 129(9):1855-65.
2015
Murlidharan G., Corriher T., Ghashghaei H.T., Asokan A. (2015) Unique glycan signatures regulate adeno-associated viral tropism in the developing brain. Journal of Virology 89(7):3976-87.
Muthusamy N., Sommerville L.J., Moeser A.J., Dykstra M.J., Stumpo D.J., Nepomuceno A., Muddiman D.C., Sannes P., Adler K.B., Blackshear P.J., Weimer J.M., Ghashghaei H.T.* (2015) MARCKS-dependent mucin trafficking and lipid metabolism in ependymal cells is required for maintenance of forebrain homeostasis during aging. Aging Cell 14(5):764-73.
Hammad M., Schmidt S.L., Zhang X., Bray R., Frohlich F., Ghashghaei H.T.* (2015) Transplantation of GABAergic interneurons into the neonatal primary visual cortex significantly reduces absence seizures in Stargazer mice. Cerebral Cortex 25(9):2970-9.
Bain L.E., Kirste R., Johnson C.A., Ghashghaei H.T., Collazo R., Ivanisevic A. (2015) Neurotypic cell attachment and growth on III-Nitride lateral polarity structures. Mater Sci Eng C Mater Biol Appl. 58:1194-8.
RosenP., BokhartM.T., Ghashghaei H.T., Muddiman D.C. (2015) Influence of Desorption Conditions on Analyte Sensitivity and Internal Energy in Discrete Tissue or Whole Body Imaging by IR-MALDESI. Journal of Am Soc Mass Spectrom. 26(6):899-910.
2014
Muthusamy N., Vijayakumar A., Cheng J.G., Ghashghaei H.T.* (2014) A knock-in Foxj1CreERT2::GFP mouse for recombination in epithelial cells with motile cilia. Genesis 52(4):350-8. COVER ILLUSTRATION
2013
Liang H., Xiao G., Yin H., Hippenmeyer S, Horowitz J.M., Ghashghaei H.T.* (2013) Neural development is dependent on the function of specificity protein 2 in cell cycle progression. Development 140(3):552-61.
Nehrenberg D.L., Sheikh A., Ghashghaei H.T.* (2013) Identification of neuronal loci involved with displays of affective aggression in NC900 mice. Brain Struct. Funct. 218(4):1033-49.
2012
Liang H., Hippenmeyer S., Ghashghaei H.T.* (2012) A Nestin-cre transgenic mouse is insufficient for recombination in early embryonic neural progenitors. Bio. Open. 15;1(12):1200-3. COVER ILLUSTRATION
2011
Jacquet B.V., Muthusamy N., Sommerville L.J., Xiao G., Liang H., Zhang Y., Holtzman M.J., Ghashghaei H.T.* (2011) Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb. J. Neurosci.31(25):9368-9382.
2010
Jacquet B.V., Ruckart P., Ghashghaei H.T.* (2010) An organotypic slice assay for high-resolution time-lapse imaging of neuronal migration in the postnatal brain. J Vis Exp. (46). pii: 2486. doi: 10.3791/2486.
Lim J.H., Piedrahita J.A., Jackson L., Ghashghaei H.T., Olby N.J. (2010) Development of a Model of Sacrocaudal Spinal Cord Injury in Cloned Yucatan MiniPigs for Cellular Transplantation Research. Cellular Reprogram 12(6):689-97.
2009
JacquetB.V., Salinas-Mondragon R., Liang H., Therit B., Buie J.D., Dykstra M., Campbell K., Ostrowski L.E., Brody S.L., Ghashghaei H.T.* (2009) FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. Development 136(23):4021-31. COVER ILLUSTRATION
Moy S.S, Nonneman R.J., Ghashghaei H.T., Weimer J.M., Yokota Y., Lee D., Lai C., Threadgill C.W., Anton E.S. (2009) Deficient NRG1-ERBB Signaling Alters Social Approach: Relevance to Genetic Mouse Models of Schizophrenia. Journal of Neurodevelopmental Disorders. Inaugural issue.
Nighot P.K., Moeser A.J., Ryan K.A., Ghashghaei T., Blikslager A.T. (2009) ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum. Exp Cell Res. 315(1):110-8.
2007
Ghashghaei H.T., Weimer J.M., Schmid R.S., Yokota Y., McCarthy K.D., Popko B., Anton E.S. (2007) Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in the adult cerebral cortex. Genes & Development 21(24):3258-71. MUST READ FACULTY OF 1000
Ghashghaei H.T., Lai C., Anton E.S. (2007) Neuronal migration in the adult brain: are we there yet? Nature Reviews Neuroscience.8(2):141-151.
Yokota Y, Ghashghaei H.T., Han C., Watson H., Campbell K.J., Anton E.S. (2007) Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex. PLoS ONE. 2(8):e794.
Ghashghaei H.T., Hilgetag C., Barbas H. (2007) Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala. NeuroImage 34(3):905-23.
2006
Ghashghaei H.T., Weber J., Pevny L., Schmid R., Schwab M.H., Lloyd K.C., Eisenstat D.D., Lai C., Anton E.S. (2006) The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proceeding of the National Academy of Sciences 103(6): 1930-1935.
Prior to 2006
Ghashghaei H.T., Anton E.S., Weber J.L., McCann C., Fischer T.M., Cheung I.D., Gassmann M., Messing A., Klein R., Schwab M.H., Lloyd K.C.K., Lai C. (2004) Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nature Neuroscience 7(12): 1319-1328.
Barbas H., Saha S., Rempel-Clower N.L., Ghashghaei H.T. (2003) Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression. Biomed Central Neuroscience 4(1):1-12.
Ghashghaei H.T. and Barbas H. (2002)< Neuroscience 115(4):1261-79.
Barbas H., Ghashghaei H.T., Rempel-Clower N.L., and Xiao, D. (2001) Anatomic basis of functional specialization in prefrontal cortices in primates. In: Handbook of Neuropsychology, Grafman J. (Ed.), Elsevier Science B.V., Amsterdam, pp. 1–27.
Ghashghaei H.T. and Barbas H. (2001) Neural interaction between the basal forebrain and prefrontal cortices in the rhesus monkey. Neuroscience 103(3):593-614.
Barbas H., Ghashghaei H.T., Dombrowski S.M., and Rempel-Clower N.L. (1999) Medial prefrontal cortices are unified by common connections with superior temporal cortices and distinguished by input from memory-related areas in the rhesus monkey. Journal of Comparative Neurology 410:343-367.